The purpose of this research is to create a learning system for blind people based on speech signals using Matlab software. Blind people often have difficulty operating on a computer, so an operator is needed to help operate it. For blind people it will be easier to do everything to operate a computer if there is an application that can operate in accordance with the orders of the blind person. Simulations are made using the Euclidean distance method and Mel-Frequency Cepstral Coefficients (MFCC) which will facilitate the human voice recognition system which was previously stored in the database. In this study, a software was made to help blind people for computer-based learning by designing various questions using audio so that blind people simply answer in a voice. The author uses the matlab software to make the software to be used. Then the results of the blind people are matched with the answers previously provided in the database.