Making stock investment decisions is a complex challenge that investors continuously face. When it comes to an uncertain future, making the wrong decision can result in massive losses. The paper aims to develop an artificial neural networks-based model predicting the closing price of top-six traded industrial ISX-listed stocks, which can guide investment decisions. The sample consisted of daily indexes ISX-released from (3/3/2019) to (31/3/2019). Matlab 2014b was used to run artificial neural networks using nntool software. Model's performance was evaluated using Mean squared error (MSE), Root mean squared error (RMSE), and R squared. Empirical results demonstrated the ability and efficiency of artificial neural networks to predict closing prices with high accuracy. As a result, we recommended employing Artificial Neural Networks model to predict stock prices as well as relying on to make decisions.